Tuesday, August 6, 2019

Improve communication Essay Example for Free

Improve communication Essay The reason why Carly didn’t come to me earlier to report the project delays was because she knew the reasons of the delay were not genuine. She was definitely part of the problem and therefore she didn’t have the language of reporting the conflict that was affecting the team project. Also, since the rest of the team knew her weakness she knew if she reported the case to me I would involve the rest of the members thus exposing her weaknesses. Carly hasn’t had a conversation with Morris about their differences despite being the supervisor since she was aware of the root cause of the problem (herself). On the other hand, Morris did not break the ice and discuss the problem with Carly because he assumed that it was Carly’s responsibility as the manager to approach and solve all differences. Furthermore, it was clear to him too of Carly’s participation in the problem. He had also been treated unfairly by Carly and this made it difficult for him to approach Carly. Coupled with the fact that Morris was more educated than Carly, pride could not be ruled out. If Morris had had a conversation with Carly, he would have mentioned about his unfair treatment to her. I tend to think since the other team members knew that Carly was treating him unfairly, this would have been his motivator to mention of this problem. He knew he had support from the entire team. As for Carly, I bet she would have owned up to this problem and promise Morris of a fair treatment in their future interactions. After such a conversation she would have realized that she was losing a key team member and the other team members had observed it previously which would also affect the whole team thus portraying her as an incompetent manager. For Carly to have been given this role of a project manager meant she had positive leadership qualities and therefore would have owned up to her failures. Failure to accept her mistake would have left her as a lone ranger thus breaking the team spirit. The biggest problem with the way these team members interacted lied on communication breakdown and barriers. This is because it’s clear the other team member had noticed the dispute but no one had shared about it with me or even asked Carly or Morris. Teamwork was minimal in this team and this would have affected this project very adversely if not handled well and quickly. To break this communication barrier and improve communication, it would be beneficial for the team to encourage more frequent and effective upward, downward and team communication. With more communication, any arising problem would be handled well in advance before affecting the project negatively. I think Carly should continue serving as the project manager. This because having discussed the dispute openly, the parties would have understood the facts of the problem and hence allow them to see their areas of agreement, thus turning the conflict into new ideas of enhancing teamwork in the project.

Monday, August 5, 2019

Cache Memory: Definition and Function

Cache Memory: Definition and Function CACHE MEMORY Cache memory is random access memory (RAM) that a pc micro chip will access a lot of quickly than it will access regular RAM. because the micro chip processes knowledge, its initial within the cache memory and if it finds the information there (from a previous reading of data), it doesnt got to do the a lot of long reading of knowledge from larger memory. Cache memory is usually delineate in levels of closeness and accessibility to the micro chip. associate L1 cache is on identical chip because the micro chip. L2 is typically a separate static RAM (SRAM) chip. the most RAM is typically a dynamic RAM (DRAM) chip. In addition to cache memory, one will think about RAM itself as a cache of memory for disc storage since all of RAMs contents return from the disc at the start. once the processor has to scan from or write to a location in main memory, it initial checks whether or not a duplicate of that knowledge is within the cache. If so, the processor straightaway reads from or writes to the cache, that is far quicker than reading from or writing to main memory. a translation look aside buffer (TLB) wont to speed up virtual-to-physical address translation for each practicable directions and knowledge. Knowledge is transferred between memory and cache in blocks of mounted size, known as cache lines. once a cache line is derived from memory into the cache, a cache entry is made. The cache entry can embody the derived knowledge in addition because the requested memory location currently known as a tag. once the processor has to scan or write a location in main memory, it initial checks for a corresponding entry within the cache. The cache checks for the contents of the requested memory location in any cache lines that may contain that address. If the processor finds that the memory location is within the cache, a cache hit has occurred. WRITE POLICY: If knowledge is written to the cache, at some purpose it should even be written to main memory. A write policy determines however the cache deals with a write cycle. The 2 common write  policies area unit Write-Back and Write-Through. WRITE BACK POLICY In Write-Back policy, the cache acts sort of a buffer. That is, once the processor starts a write cycle the cache receives the information and terminates the cycle. The cache then writes the information back to main memory once the system bus is offered. This technique provides the best  performance by permitting the processor to continue its tasks whereas main memory is updated at a  later time. However, dominant writes to main memory increase the cache’s quality and  cost. WRITE THROUGH POLICY The second technique is that the Write-Through policy. because the name implies, the processor writes through the cache to main memory. The cache could update its contents, but the write cycle doesnt finish till the information is keep into main memory. This technique is a smaller amount advanced. The primary drawback with write-through caches is their higher write traffic as compared to write-back caches. a method to scale back this traffic is to use a coalescing write buffer, wherever writes to addresses already within the write buffer area unit combined. once a write misses within the write cache, the LRU entry is transferred to the write buffer to create area for the present write. In actual implementation, the write cache may be integrated with a coalescing write buffer. Write through policy is most prefererable in memory application than write back policy as a result of it embody the property of automatic update once any changes occur in cache block itll replicate into main memory. CONVENTIONAL 2 LEVEL CACHE Fig. 3illustrates the design of the two-level cache. solely the L1 knowledge cache and L2 unified cache area unit shown because the L1 instruction cache solely reads from the L2 cache. below the write through policy, the L2 cache continuously maintains the foremost recent copy of the information. Thus, whenever a knowledge is updated within the L1 cache, the L2 cache is updated with identical knowledge in addition. This ends up in a rise within the write accesses to the L2 cache and consequently a lot of energy consumption. The locations (i. e. , approach tags) of L1 knowledge copies within the L2 cache wont modification till the information area unit evicted from the L2 cache. The planned way-tagged cache exploits this reality to scale back the quantity of the way accessed throughout L2 cache accesses. once the L1 knowledge cache masses a knowledge from the L2 cache, the approach tag of the information within the L2 cache is additionally sent  to the L1 cache and keep during a new set of approach-tag arrays These way tags give the key data for the following write accesses to the L2 cache. In general, each write and browse accesses within the L1 cache may have to access the L2 cache. These accesses result in totally different operations within the planned way-tagged cache, as summarized in Table I. below the write-through policy, all write operations of the L1 cache got to access the L2 cache. within the case of a write hit within the L1 cache, only 1 approach within the L2 cache are going to be activated as a result of the approach tag data of the L2 cache is offered, i. e. , from the approach-tag arrays we are able to acquire the L2 way of the accessed knowledge. whereas for a write miss within the L1 cache, the requested knowledge isnt keep within the L1 cache. As a result, its corresponding L2 approach data isnt offered within the way-tag arrays. Therefore, all ways that within the L2 cache got to be activated at the same time. Since write hit/miss isnt proverbial a priori, the way-tag arrays got to be accessed at the same time with all L1 write operations so as to avoid performance degradation. Note that the way-tag arrays area unit terribly little and also the concerned energy overhead may be simply salaried for (see section). For L1 scan operations, neither scan hits nor misses got to access the way-tag arrays. this is often as a result of scan hits dont got to access the L2 cache; whereas for scan misses, the corresponding approach tag data isnt offered within the way-tag arrays. As a result, all ways that within the L2 cache area unit activated at the same time below scan misses. PROPOSED approach TAG CACHE we tend to introduce many new components: way-tag arrays, way-tag buffer, approach decoder, and approach register, all shown within the line. The approach tags of every cache line within the L2 cache area unit maintained within the way-tag arrays, set with the L1 knowledge cache. Note that write buffers area unit normally used in write through caches (and even in several write-back caches) to boost the performance. With a write buffer, the information to be written into the L1 cache is additionally sent to the write buffer. The operations keep within the write buffer area unit then sent to the L2 cache in sequence. This avoids write stalls once the processor waits for write operations to be completed within the L2 cache. within the planned technique, we tend to conjointly got to send the approach tags keep within the way-tag arrays to the L2 cache at the side of the operations within the write buffer. Thus, alittle approach-tag buffer is introduced to buffer the way tags scan from th e way-tag arrays. {a approach|how|some way|the way|the simplest way} rewriter is used to decode way tags and generate the alter signals for the L2 cache, that activate solely the specified ways that within the L2 cache. every approach within the L2 cache is encoded into the simplest way tag. {a approach|how|some way|the way|the simplest way} register stores way tags and provides this data to the way-tag arrays. IMPLEMENTATION OF WAY-TAGGED CACHE WAY-TAG ARRAYS Way tag arrays have approach tags of a knowledge is loaded from the L2 cache to the L1 cache, shown in Fig three. Note that {the knowledge|the info|the information} arrays within the L1 data cache and also the way-tag arrays share identical address from hardware. The WRITEH_W signal of way-tag arrays is generated from the write/read signal of {the knowledge|the info|the information} arrays within the L1 data cache as shown in Fig. 8. A UPDATE is management signal, obtained from the cache controller. once a L1 write miss, UPDATE are going to be declared and permit WRITEH_W to alter the write operation to the way-tag arrays (UPDATE=1 and WRITEH_W, See Table II). UPDATE keeps invalid and WRITEH_W =1, a scan operation to the way-tag arrays. During the scan operations of the L1 cache, the way-tag arrays dont got to be accessed and so, scale back energy overhead. to attenuate the overhead of approach tag arrays, the scale of a way-tag array may be expressed as Where SL1, Sline,L1 and Nway,L1 area unit the scale of the L1 knowledge cache, cache line size and variety of the ways that within the L1data cache severally. Bway,L2= may be a code. The way-tag arrays area unit operated in parallel with the L1 knowledge cache for avoiding the performance degradation. as a result of their little size, the access delay is far smaller than that of the L1 cache. WAY-TAG BUFFER Way-tag buffer is quickly stores the approach tags from the way-tag arrays within the L1 cache. its identical variety of entries because the write buffer of the L2 cache and shares the management signals with it. Note that write buffers area unit normally used, the information to be written into the L1 cache is additionally sent to the write buffer to boost the performance. This avoids write stalls once the processor waits for write operations to be completed within the L2 cache. When a write miss happens in L1 cache, all the ways that within the L2 cache got to be activated because the approach data isnt offered. Otherwise, solely the specified approach is activated. approach tag buffer is little in to avoid space overhead. Approach DECODER The operate of the approach rewriter is used to decode approach tags and generate the alter signal, that activate solely desired ways that in L2 cache. This avoids the extra wires and also the chip space is negligible. A write hit within the L1 cache, the approach decoder works as associate n -to- N decoder that selects one way-enable signal. For a write miss or a scan miss within the L1 cache, the approach decoder assert all way-enable signals, in order that all ways that within the L2 cache area unit activated. Approach REGISTER The approach tags for the way-tag arrays is Provided by approach register. A 4-way L2 cache is take into account, that labels â€Å"00†, â€Å"01†, â€Å"10†, andâ€Å"11†. This area unit keep within the approach register. once the L1 cache masses a knowledge from the L2 cache, the corresponding approach tag within the approach register is distributed to the approach-tag arrays by this way the corresponding way tags area unit keep in way-tag array. The planned approach-tagged caches way operates below totally different modes throughout scan and write operations. solely the approach containing the specified knowledge is activated within the L2 cache for a write hit within the L1 cache, operating the L2 cache equivalently a direct-mapping cache to scale back energy consumption while not performance overhead below the write-through policy. APPLICATION OF approach TAGGING IN PHASED ACCESS CACHES In this section, we are going to show that the thought of approach tagging may be extended to alternative low-power cache style techniques suchas the phased access cache [18]. Note that since the processor performance is a smaller amount sensitive to the latency of L2 caches, several processors use phased accesses of tag and knowledge arrays in L2 caches to scale back energy consumption. By applying the thought of approach tagging, any energy reduction may be achieved while not introducing performance degradation. In phased caches, all {ways|ways that|ways in that} within the cache tag arrays got to be activated to work out which approach within the knowledge arrays contains the specified knowledge (as shown within the solid-line a part of Fig. 8). within the past, the energy consumption of cache tag arrays has been unnoticed as a result of their comparatively little sizes As superior microprocessors begin to utilize longer addresses, cache tag arrays become larger. Also, high associativity is vital for L2 caches in bound applications. These factors result in the upper energy consumption in accessing cache tag arrays. Therefore, its become vital to scale back the energy consumption of cache tag arrays. the thought of approach tagging may be applied to the tag arrays of phased access cache used as a L2 cache. Note that the tag arrays dont got to be accessed for a write hit within the L1 cache (as shown within the dotted-line half in Fig. 9). {this is|this is often|this may be} as a result of the destination approach of knowledge arrays can be determined directly from the output of the approach decoder shown in Fig. 7. Thus, by accessing fewer ways that within the cache tag arrays, the energy consumption of phased access caches may be any reduced The operation of this cache is summarized in Fig. 9. Multiplexor M1 is used to get the alter signal for the tag arrays of the L2 cache. once the standing bit within the way-tag buffer indicates a write hit, M1 outputs â€Å"0† to disable all the ways that within the tag arrays. As mentioned before, the destination approach of the access may be obtained from the approach decoder and so no tag comparison is required during this case. Multiplexor money supply chooses the output from the approach decoder because the choice signal for the information arrays. If on the opposite hand the access is caused by a write miss or a scan miss from the L1 cache, all ways that area unit enabled by the tag array decoder, and also the results of tag comparison is chosen by money supply because the choice signal for the information arrays. Overall, fewer ways that within the tag arrays area unit activated, thereby reducing the energy consumption of the phased access cache. Note that the phased ac cess cache divides associate access into 2 phases; so, money supply isnt on the crucial path. Applying approach tagging doesnt introduce performance overhead as compared with the standard phased cache. Common or Shared LUT design A shared or common LUT design is planned to be applied in knowledge array management of this cache design. Since knowledge array in cache design is related to electronic device choice based mostly processor for knowledge accessing, we tend to area unit introducing associate shared LUT during which all knowledge data is loaded with table loader per is index and coefficients for knowledge finding and matching allocation throughout cache operations. thus knowledge array may be replaced by shared LUT design with effectively acts and reduces the whole power consumption of overall approach tag array cache design. From the fig. 7. the shared LUT design is divided in to four banks with several address related to it. If a processor has to access knowledge from bank three, itll directly access that data via its constant bit address by matching with table loader indexes. Hence a protracted looking method is proscribed to direct accessing technique through shared LUT design. Apart from banks it conjointly has SFU-Special practical Units in it. its connected to table loader. These SFU’s will access all the banks by having easy indexes like â€Å"000† the primary zero represents the quantity of SFU i. e SFU 0. thus the remainder 2 zero’s represents the bank constant. By bit matching, SFU simply connects with bank zero that contain relevant knowledge access in cache operations. If SFU0 and SFU one having values like â€Å"000† and â€Å"100† then confusion is cleared by higher priority portal. the upper priority is nothing however one that comes initial is allowed to access the information initial too. the remainder request signals accessed in  Ã‚  parallel at that time.

Sunday, August 4, 2019

Tragic Heros In Shakespeare

Tragic Heros In Shakespeare Macbeth serves as an example of a tragic hero in Shakespeare s Macbeth. His tragic decision stems from the influence of a tragic flaw. Once he has made the decision, it is irreversible, and produces his downfall. In an attempt to save himself, the tragic hero tries to reverse his decision, but ultimately fails. The tragic hero must be neither villain nor a virtuous man but a character between these two extremes. A man who not eminently good and just, yet whose misfortune is brought about not by vice or depravity but by some error or human frailty. 1st Paragraph: Topic sentence: At the very beginning of the play, Macbeth and Banquo are returning to Scotland. Won the war for Duncan. Shows a noble virtue of Macbeth, a requirement of a tragic hero Three witches appear and make prophecies about Macbeth and Banquo. All hail, Macbeth! Hail to thee, thane of Glamis! All hail, Macbeth! hail to thee, thane of Cawdor! All hail Macbeth that shalt be king hereafter! (I,ii,48). Ross enters tells Macbeth is thane of Cawdor now. Macbeth is surprised. Prophecies coming true. Duncans sons, would be the rightful heirs to the throne. Nowhere near the next in line to the throne Closing sentence: Macbeths tragic flaw is that of ambition; Macbeths ambition will cause him to decline. 2nd Paragraph: Topic Sentence: At this point, Lady Macbeth knows all about the witches prophecies. Lady Macbeth wants to be Queen of Scotland, encourages Macbeth to get rid of Duncan. After killing Duncan, Macbeth feels sorry for himself. His ambition has caused him to kill a good friend and even worse, the King! Macbeth brings dagger back. Lady Macbeth gets angry but Macbeth says: Ill go no more; I am afraid to think what I have done; Look on t again I dare not. (II,ii,51). Lady Macbeth controls and tell him: a little water clears us of this deed. (II,ii,67) Macbeth becomes satisfied with what he has done especially after Malcolm and Macduff leaves Scotland. The third prophecy has come true; Macbeth is King of Scotland! Macbeth wants Banquo and his son dead because of the witches prophecy that Banquos sons will become Kings. He hires three murderers to kill Banquo and his son Fleance. Fleance escapes. Macbeth is outraged when he hears this. He says: Then comes my fit again; I had else been perfect, Whole as the marble, founded as the rock, As broad and general as the casing air. But now I am cabined, cribbed, confined, bound in To saucy doubts and fears. But Banquos safe? (III,ii,21). Macbeth sees the ghost of Banquo at the banquet. Macbeth says Which of you have done this? and Thou canst not say I did it; never shake thy gory locks at me. (III,iv,48). Lady Macbeth senses that something is definitely wrong and she asks everyone to leave immediately. Macbeth is shown as a hubris character. Closing Sentence: He was not afraid of the consequences of his actions although he knew very well what they would be. This is another tragic flaw. 3rd Paragraph: Topic Sentence: Macbeth is worried and goes to meet the witches. First apparition: Macbeth! Macbeth! Macbeth! Beware Macduff; Beware the thane of Fife. Second apparition: The power of man, for none of woman born shall harm Macbeth. Third apparition: Macbeth shall never vanquishd be until Great Birnam wood to high Dunsinane hill. Shall come against him. Macbeth is scarred and says: Seize upon Fife; give to the edge o the sword. His wife, his babes, and all unfortunate souls.(IV,I,151) He is scared by the apparitions prophecies and wants to kill anyone who comes in his way. Macbeth thinks he has it made; that nothing can take his crown away from him now. Birnam woods climb the hill in form of the Malcolm army.(Third prophecy comes true) Macbeth is shown once again at the end of the play when Macduff challenges Macbeth to a fight. Macbeth says he will not fight, so Macduff says: Then yield thee, coward (V, viii, 23). Macbeth answers: I will not yield (V, viii, 28). Macbeth finally realizes what he has done and how the witches prophecies and apparitions have all come true. Fights back but is killed by Macduff. (Second and First prophecy comes true) Closing Sentence: But he did not just give up like a coward. He fought like the great warrior he once was. Conclusion: In conclusion, Macbeth was a noble, honest, authentic man. However, Macbeth, tragically followed the Witches philosophy in life, fair is foul and foul is fair. The constant fricative sound in this alliteration infers the bitter outlook the Witches have towards life; and henceforth creates the appearance that unless Macbeth changes, he will be damned to this embittered panorama, therefore he decides to change, following the witches prophecy that thou shalt be king hereafter . He decrees that he shall follow this prophecy and do anything to become the king. the prophecies given to him by the witches, Lady Macbeths influence and plan, and his intensified ambition, all contributed greatly to his degeneration of character which resulted to his downfalldeath. Therefore Macbeth character displays strong signs of a tragic hero, making him the ideal classic example. -Palash jain 1(A)

The Revenge of Iago in Shakespeares Othello :: Othello essays Shakespeare

The Revenge of Iago in William Shakespeare's Othello In Shakespeare's "Othello," Iago carefully and masterfully entraps Othello into believing that his wife, Desdemona, is having an affair with Cassio. He does this through a series of suggestions and hesitations that entice and implant images into Othello's head that lead him to his own demise. More importantly, Iago gives Othello the motive to murder his own innocent wife Desdemona, satisfying Iago's immense appetite for revenge. The motive for Iago's devious plan is initially made clear in the first of three major soliloquies, in which he proclaims Othello has had an affair with his wife, Emilia: "And it is thought abroad that t'wixt my sheets/ He's done my office" (I.iii.381-383). The irony behind this line is where he continues: "I know not if't be true/ But I, for mere suspicion in that kind; / Will do as if for surety"(I.iii.383-385). Iago is so exceedingly paranoid and insane that he will go far as murdering, and deluding even a general into murdering his wife. Iago simultaneously conducts a devious plan to obtain Cassio's position as lieutenant, using Desdemona's prime weakness; her naivety. He disgraces Cassio by intoxicating him enough so he strikes Roderigo. Othello then discharges Cassio of his Lieutenancy when he says: "Cassio, I love thee,/ But nevermore be officer of mine" (II.iii.242-244). It was therefore understandable that he would fall to the mercy of Iago, completely oblivious to the inevitable effects. Iago reveals his plan to the reader in his third soliloquy when he states:      Ã‚  Ã‚  Ã‚  Ã‚   His soul is so unfettered to her love,   Ã‚  Ã‚  Ã‚  Ã‚   That she may make, unmake, do what she list,   Ã‚  Ã‚  Ã‚  Ã‚   even as her appetite shall play the god   Ã‚  Ã‚  Ã‚  Ã‚   With his weak function...   Ã‚  Ã‚  Ã‚  Ã‚   And she for him pleads strongingly to the Moore,   Ã‚  Ã‚  Ã‚  Ã‚   I'll pour this pestilence into his ear:   Ã‚  Ã‚  Ã‚  Ã‚   That she repels him for her body's lust,   Ã‚  Ã‚  Ã‚  Ã‚   And by how much she strives to do him good,   Ã‚  Ã‚  Ã‚  Ã‚   She shall undo her her credit with the Moor (II.iii.330-350). The first instance of this plan comes to life in the scene where Iago gets Cassio drunk, but the crafting only begins after Cassio is dismissed by Othello. With Cassio's reputation squandered, Iago subsequently hooks in Cassio by taking advantage of the fact that he is in a state in which he would do anything to acquire his job, position, and reputation back. The Revenge of Iago in Shakespeare's Othello :: Othello essays Shakespeare The Revenge of Iago in William Shakespeare's Othello In Shakespeare's "Othello," Iago carefully and masterfully entraps Othello into believing that his wife, Desdemona, is having an affair with Cassio. He does this through a series of suggestions and hesitations that entice and implant images into Othello's head that lead him to his own demise. More importantly, Iago gives Othello the motive to murder his own innocent wife Desdemona, satisfying Iago's immense appetite for revenge. The motive for Iago's devious plan is initially made clear in the first of three major soliloquies, in which he proclaims Othello has had an affair with his wife, Emilia: "And it is thought abroad that t'wixt my sheets/ He's done my office" (I.iii.381-383). The irony behind this line is where he continues: "I know not if't be true/ But I, for mere suspicion in that kind; / Will do as if for surety"(I.iii.383-385). Iago is so exceedingly paranoid and insane that he will go far as murdering, and deluding even a general into murdering his wife. Iago simultaneously conducts a devious plan to obtain Cassio's position as lieutenant, using Desdemona's prime weakness; her naivety. He disgraces Cassio by intoxicating him enough so he strikes Roderigo. Othello then discharges Cassio of his Lieutenancy when he says: "Cassio, I love thee,/ But nevermore be officer of mine" (II.iii.242-244). It was therefore understandable that he would fall to the mercy of Iago, completely oblivious to the inevitable effects. Iago reveals his plan to the reader in his third soliloquy when he states:      Ã‚  Ã‚  Ã‚  Ã‚   His soul is so unfettered to her love,   Ã‚  Ã‚  Ã‚  Ã‚   That she may make, unmake, do what she list,   Ã‚  Ã‚  Ã‚  Ã‚   even as her appetite shall play the god   Ã‚  Ã‚  Ã‚  Ã‚   With his weak function...   Ã‚  Ã‚  Ã‚  Ã‚   And she for him pleads strongingly to the Moore,   Ã‚  Ã‚  Ã‚  Ã‚   I'll pour this pestilence into his ear:   Ã‚  Ã‚  Ã‚  Ã‚   That she repels him for her body's lust,   Ã‚  Ã‚  Ã‚  Ã‚   And by how much she strives to do him good,   Ã‚  Ã‚  Ã‚  Ã‚   She shall undo her her credit with the Moor (II.iii.330-350). The first instance of this plan comes to life in the scene where Iago gets Cassio drunk, but the crafting only begins after Cassio is dismissed by Othello. With Cassio's reputation squandered, Iago subsequently hooks in Cassio by taking advantage of the fact that he is in a state in which he would do anything to acquire his job, position, and reputation back.

Saturday, August 3, 2019

The Role of Polyglutamine Expansions in Huntington’s Disease Essay

Huntington’s disease (HD) is a neurodegenerative dominant disorder caused by the expansions of polyglutamine in the gene encoding for Huntington’s protein. It is a developmental autosomal brain disorder that affects muscle coordination, emotional and personality problems. As well as subcortical dementia, further leading to cognitive decline this is all related with selective neuronal cell death mainly associated in the striatum and cortex (Scherzinger et al., 1997). HD causes emotional problems, uncontrolled movements and the loss of thinking ability. It can lead to disability and death from the illness. There are two forms of this disease: adult-onset and early-onset (juvenile). Adult onset is by the far most common for HD; symptoms develop between the ages of mid 30s/40s, an individual will live an average of 20 years after symptoms and signs begin. Premature signs and symptoms are depression, involuntary movements, trouble learning new information, poor coordination; this can all progress very severely. The development of pre-disease symptoms into twitching or jerking is referred as Chorea. HD can be referred to Huntington Chorea. Although adult onset is more common disorder, juvenile form, defined by the onset of signs and symptoms before the age of 21 years, this occurs in about 7% of HD cases. (Nance, 2001) Juvenile onset has similar symptoms however the disease progresses more quickly compared to the adult onset form. Gente (1985) results showed findings by others, that the most juvenile-onset patients inherit the gene from their fathers and that the late-onset form is more frequently inherited from affected mothers. HD occurs due to CAG/polyglutamine(polyQ) expansions, in the first exon of a gene encoding a la... ..., C. and Bates, G, P. (2004). Huntingtin and the molecular pathogenesis of Huntington’s disease. EMBO reports 5. 958-963 Nance, M, A. and Myers, R, H. (2001) Panov, A, V., Gutekunst, C., Leavitt, B, R., Hayden, M, R., Burke, J, R., Strittmatter, W, J. And Greenamyre, J, T. (2002) Early mitochondrial calcium defects in Huntington’s Disease are a direct effect of Polyglutamines. Nature neuroscience. Volume 5 no 8 Ross, C, A. (2002). Polyglutamine Pathogenesis: Emergence of Unifying Mechanism for Huntington’s Disease and Related Disorders. Neuron, Vol. 35,819-822. Scherzinger, E., Lurz, R., Turmaine, M., Mangiarini, L., Hollenbach, Birgit., Hasenbank, R., Bates, G, P., Davies, S, W., Lehrach, H and Wanker, E, E. (1997). Huntington-Encoded Polyglutamine Expansions Form Amyloid-like Protein Aggregates In Vitro and In Vivo. Cell, Vol.90, 549-558. Zhang,

Friday, August 2, 2019

Irish Urban Land Development Essay

Currently, Ireland is classified as a First World Economy and it has experienced exceptional economic development at an average rate of eight per cent per year between 1994 and 2001, with a humble growth rate of four per cent per year as from 2001 to date (Stewart 2005). With this rate of growth, Ireland has become more urbanized with increased population, changing agricultural practices, and reformation of local authorities to hold increased public participation and boost lucidity. In addition, there has been a change in the household development, an escalating number and forms of homes with a changing tenure system accompanied by population changes. These elements together with the exceptional economic development and low interest rates have changed the economic, environmental and social outlook of Ireland. The changes have presented numerous challenges such as traffic clogging, environmental squalor, urban sprawl, and lack of affordable housing. This has led to a broken nexus between economic development and human welfare (Drudy 1982). Ireland has had several mechanisms aimed at effecting efficient land use planning within the urban environment towards achieving sustainable development. These mechanisms include an abundance of policies and strategies. These policies and strategies include sustainable development, a strategy for Ireland 1997, National spatial strategy for Ireland 2002, and National development plan 2002-2006 among others. However, even with these initiatives, numerous challenges still persist for urban and regional policy-making in the search of an effective and efficient sustainable development (Stewart 2005). It can be debated that some political, social, and economic elements do repel policy impact from policies intentions considering the extent to which current challenges continue to exist (EU Commission 2001). Much of research related to urbanization of population is colored with powerful anti-urbanism and a desire after the values and simple life styles of traditional upcountry areas. In Ireland some research on urbanization too stresses the goodness of upcountry and the cons of urban trends. These biases are more apparent in the research and policies related to urban land and urban advancement onto agricultural land (Drudy 1982). In fact, the preservation and defense of agricultural land and rural facilities has been the force behind the ratification of physical planning laws (Bengston et al 2004). During the late 17th and 18th centuries the existing urban model was increased by establishment of great number of new towns and villages together with re-development and extension of the existing settlements. It is argued that most of the Irish town begun as a village and outgrew into modest origins by the end of 18th century. These growths were as a result of network of roads and new canal system linking the rural and the major towns and this served as a reinforcement of the dominance of Dublin which was by then the best peopled town (Drudy 1982). The escalating growth of Irish urban regions particularly Dublin presented severe land, energy and social impacts. Growth was limited to a ring of suburban prompting rapid population increase with extreme demand for school, shopping centre, transport systems and local employment. This demand called for more land thus increasing pressures on agricultural land for urban development. Irish dedication to sustainable development can be measured by looking at its housing and land-use policies. The development of one off housing in the rural areas is the significant sign of urban sprawl. In a nation marked with a growing ratio of low density space, the prevalence of one off housing suggestion is a wholesome system failure (Bengston et al 2004). Irish land use is mostly governed by local government development plans but implementation of policies are not uniform. Viewing the one-off housing policy under the economies of scale, the houses are more expensive in service provision but a lot of burden to the developer, house purchaser and even Irish community at large. This is echoed by EPA which state that single housing homes in the upcountry leads to greater car usage therefore increasing energy demands and greater usage of small waste water treatment facilities which have the tendency to pollute underground water (Bengston et al 2004). The opposition of one off housing focuses on the economic burdens for its occupants and on the exchequer. However, when placed on a national framework, there are unquestionably broader economic challenges at stake. For example the impact of sustained site sales on Irish agricultural commodities. The sale of some areas has benign effects on agricultural activities. The fact is that site sale shackle Ireland farming over medium and long-term. Smart Growth an Option for Ireland Smart growth model was born in US in the 90s and this concept entails identifying a common platform where developers, the public and public officials together with environmentalists among other stakeholders finds acceptable means of accommodating growth. The smart growth approach emphasizes on integrating economic, social, and environmental elements of planning and development. It is not an anti-development approach as many may argue but equivalent of the bigger picture of sustainable development as defined by Bruntland as development that provides the requirements of the current generation without jeopardizing the capacity of the same resources to provide the needs of the future generations (Bruntland 1987). The concept imply to offer an answers towards managing growth through public policies instruments for example regulatory instruments and fiscal policies such as incentives and disincentives aiming at accommodating growth in ways that are economically feasible, environmentally friendly and enhancing quality of life. Some of the concerns that the approach targets to address is traffic congestion, urban sprawl, overcrowding and pollution (Stewart 2005). Conclusion The global essential towards achievement of sustainable growth implies that it is important to seek means to accommodate development in ways that is economically feasible, environmentally friendly, and socially responsible. One of the major critics of traditional urban planning is that the concept, method and technique engaged lean towards re-enforcing the present. This makes it challenging for town and city to reflect, plan and establish future alternative ideas suiting to all stakeholders’ true requirements. There is a dire necessity of replacing the conventional short term quick fix model to long term integrating and holistic model in the planning and development strategies. There is need for collaboration on finding solutions and powerful political leadership for Ireland to progress from rhetoric to reality in delivering it land use policies that will lead to positive, efficient and sustainable communities. Smart growth is not a solution to development concerns but an alternative approach to the present development model and a feasible way of mitigating current and probable future social economic and environmental concerns (Stewart 2005).

Thursday, August 1, 2019

Comparative Analysis of Differenet Forms of Business

AHSAN JAVED 11P0023 MBA 1(A) Assignment 1 Corporate Finance Submitted to: Sir kumail Rizvi Comparative analysis of different forms of business organization Ownership A sole proprietorship has only a single owner. A partnership has two or more owners. A corporation can have an unlimited number of owners. Liability In Sole proprietorship the liability is unlimited; owners are responsible for whatever profit the business gets and whatever loss the business incurs. In partnerships the profits and liability are distributed between the two or more owners according to their shares. In Corporations there is limited liability, and in case of failure shareholders may lose their investment but he/she will not be liable to any debts of the corporations. Life of the business The life of the business in sole proprietorship depends on the life of the owner. In partnerships, it ends with death, bankruptcy of partner. In corporations, a corporation does not expire upon the death of its shareholders, directors or officers. Excess to Capital In Sole proprietorship the excess to capital is very limited. In partnerships the excess to capital is more then sole proprietorship but much less then corporations. Corporations have excess to great amount of capital. Management In sole proprietorship, single owner does all the management of the business. In partnerships, owner’s agreement on management is required. In corporations, board of directors appoints the management team. Ease of setting up Sole proprietorship is quite easy to setup and there are usually no legal agreements required. Partnerships are also easy to setup but there are legal agreements between the owners and usually some paperwork required. Corporations are more difficult and costly to set up, often requiring state applications, legal paperwork such as articles of incorporation, board resolution and affidavit. Tax Structure In Sole proprietorship, the business and the owner is treated as one so the tax is being filed on the owners income. In partnerships the tax is being filed on the incomes of the partners. In case of corporations, the tax is being filed on the shareholders on the dividends they receive as well as on the income of the corporation.